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KMID : 0616119840150010052
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Korean Journal of Pharmacognosy
1984 Volume.15 No. 1 p.52 ~ p.52
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The Proceedings of 14th Annual Convention ( 1983 ) ; The Effect of Some Spices on Liver Drug Metabolizing Enzymes
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신국현/Shin KH
우원식/신양미/한용봉/황영랑/Woo WS/Shin YM/Han YB/Hwang YR
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Abstract
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The effect of some spices on liver drug metabolizing activity was evaluated by measuring the duration of hexobarbital-induced hypnosis in mice. The experimental results obtained with 22 plant extracts were as follows; Oral administration of seven plant extracts such as Fennel seeds, Dill weads, Nutmeg, White pepper, Mace (aril), Sage leaves and Paprika to mice daily for 7 days caused a significant shortening effect on the duration of sleeping time. The treatment of mice with a single i.p. injection of 9 plant extracts resulted in a significant prolongation of sleeping time. These results strongly indicated that some spices might affect the activity of liver microsomal enzyme systems.
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